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Absorption and excretion of tolmetin in man
Author(s) -
Cressman William A.,
Wortham G. Forrest,
Plostnieks Janis
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976192224
Subject(s) - aspirin , pharmacokinetics , salicylic acid , absorption (acoustics) , nonsteroidal , chemistry , pharmacology , excretion , plasma concentration , urine , metabolism , drug , endocrinology , medicine , biochemistry , physics , acoustics
Tolmetin, a nonsteroidal anti‐inflammatory drug, is rapidly absorbed (10 to 20 min) and rapidly excreted (T½ ≃ 60 min) and shows a linear dose‐plasma level response in the therapeutic dose range. Tolmetin does not affect its own metabolism on chronic administration. Tolmetin is displaced, in vitro, from plasma proteins by salicylic acid. This effect is reflected in minor changes in plasma levels and pharmacokinetic parameters when aspirin and tolmetin are coadministered.