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Hypnotic efficacy of lorazepam and flurazepam
Author(s) -
Wang Richard I. H.,
Stockdale Susan L.,
Hieb Elizabeth
Publication year - 1976
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1976192191
Subject(s) - flurazepam , lorazepam , hypnotic , placebo , crossover study , anesthesia , temazepam , medicine , psychology , benzodiazepine , receptor , alternative medicine , pathology
In a double‐blind crossover study involving 15 insomniac subjects, the hypnotic efficacy of lorazepam, 2 and 4 mg, was compared with flurazepam, 15 and 30 mg, and placebo. Five subjective measures were used: onset, length, and depth of sleep, number of times awakened, and satisfaction with the hypnotic. Lorazepam in 2‐ and 4‐mg doses was comparable in hypnotic efficacy to flurazepam, 30 mg, according to most parameters of measurement. Side effects were minor, although relatively numerous at the 4‐mg doses.