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Effect of oral contraceptives on plasma clearance
Author(s) -
Carter Dean E.,
Bressler Rubin,
Hughes Mark R.,
Haussler Mark R.,
Christian C. Donald,
Heine M. Wayne
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975186700
Subject(s) - mestranol , phenylbutazone , plasma clearance , medicine , steroid , pharmacokinetics , endocrinology , half life , plasma concentration , plasma levels , population , hormone , family planning , research methodology , environmental health
The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half‐lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half‐life was increased in 3 of 6 subjects, phenylbutazone half‐life was not consistently altered, and vitamin Da half‐life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid therapy, the antipyrine half‐life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.