Effect of oral contraceptives on plasma clearance | Zendy

Carter Dean E. | Zendy; Bressler Rubin | Zendy; Hughes Mark R. | Zendy; Haussler Mark R. | Zendy; Christian C. Donald | Zendy; Heine M. Wayne | Zendy

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Effect of oral contraceptives on plasma clearance

Author(s) -

Carter Dean E.,

Bressler Rubin,

Hughes Mark R.,

Haussler Mark R.,

Christian C. Donald,

Heine M. Wayne

Publication year - 1975

Publication title -

clinical pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.941

H-Index - 188

eISSN - 1532-6535

pISSN - 0009-9236

DOI - 10.1002/cpt1975186700

Subject(s) - mestranol , phenylbutazone , plasma clearance , medicine , steroid , pharmacokinetics , endocrinology , half life , plasma concentration , plasma levels , population , hormone , family planning , research methodology , environmental health

The effects of chronic steroid contraceptive therapy on drug clearance from plasma were studied by using plasma antipyrine, phenylbutazone, and cholecalciferol half‐lives in women. After 3 mo of oral steroid therapy (Norinyl, 2 mg; norethindrone + mestranol), the antipyrine half‐life was increased in 3 of 6 subjects, phenylbutazone half‐life was not consistently altered, and vitamin Da half‐life was increased in 3 of 4 patients. After 1 to 7 yr of oral steroid therapy, the antipyrine half‐life was longer while taking the contraceptive than when the contraceptive treatment was discontinued in 4 of 6 subjects, whereas that of phenylbutazone was not consistently altered.

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