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Nefopam and morphine in man
Author(s) -
Sunshine Abraham,
Laska Eugene
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975185part1530
Subject(s) - morphine , analgesic , medicine , adverse effect , potency , anesthesia , pharmacology , chemistry , biochemistry , in vitro
A new analgesic, nefopam, is chemically distinct and pharmacologically unrelated to any presently known analgesic. A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2‐dose level, double‐blind design. A significant dose‐response curve was obtained with nefopam and with morphine, and there was no significant deviation from parallelism. The time‐effect curves for the 2 drugs were similar. The estimated relative potency of nefopam to morphine indicates that 20 mg of neJopam HCI is the approximate analgesic equal of 12 mg of morphine SO 4 . There were no adverse effects with nefopam and one adverse reaction to morphine.