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Combination 6‐mercaptopurine‐adriamycin in refractory adult acute leukemia
Author(s) -
Rodriguez Victorio,
Bodey Gerald P.,
McCredie Kenneth B.,
Freireich Emil J.,
Minow Robert A.,
Casey John H.,
Luna Mario
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975184462
Subject(s) - medicine , mercaptopurine , prednisone , refractory (planetary science) , vincristine , cholestasis , leukemia , gastroenterology , chronic myelogenous leukemia , chemotherapy , cyclophosphamide , physics , astrobiology
Remission induction therapy with 6MP and adriamycin in combination was administered to 19 adult leukemic patients refractory to previous therapy. Eight patients also received vincristine and prednisone. Thirteen patients had acute myelogenous leukemia, 3 undifferentiated leukemia, and 3 blastic transformation of chronic myelogenous leukemia. Four patients who died of severe infection received less than 6 wk of therapy. Four patients achieved remission but in only 2 were the remissions complete. Eleven patients failed to respond. Ten of the 19 patients developed unexpected severe liver toxicity manifested by a clinical picture of cholestasis (in the majority) or ascending cholangitis (in 2 patients). In the postmortem examination of 8 patients there was cholestasis and mild to severe hepatocellular damage in all.