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Biopharmaceutic influences on the anticholinergic effects of propantheline
Author(s) -
Gibaldi Milo,
Grundhofer Barbara
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975184457
Subject(s) - anticholinergic , ingestion , medicine , anticholinergic agents , anesthesia
With reduction of salivary flow rate as an index of anticholinergic response, 3 subjects manifested demonstrable effects shortly after ingestion of 15‐mg doses of propantheline in conventional tablets. Ingestion of this dose immediately after a standardized breakfast substantially reduced the anticholinergic effects. In 1 subject, a dose‐response relationship was noted after 15 mg and 30 mg doses under both fasting and fed conditions, but at each dose level the influence of food was clear. Administration of a 30‐mg dose of propantheline in a commercially available “prolonged‐acting” tablet induced little if any anticholinergic effects; in 2 subjects, marginal but fleeting indications of salivary suppression were noted about 4 hr after ingestion, while no effects were observed in the third subject (even after 2 “prolonged‐acting” tablets).