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Interactions of levodopa with inhibitors of monoamine oxidase and L‐aromatic amino acid decarboxylase
Author(s) -
Teychenne Paul F.,
Calne Donald B.,
Lewis Peter J.,
Findley Leslie J.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975183273
Subject(s) - tranylcypromine , carbidopa , levodopa , aromatic l amino acid decarboxylase , parkinsonism , monoamine oxidase , pharmacology , chemistry , monoamine oxidase inhibitor , decarboxylase inhibitor , medicine , biochemistry , enzyme , parkinson's disease , disease
Drug interactions between levodopa, tranylcypromine, and carbidopa have been studied in 4 patients with idiopathic parkinsonism. Pressor responses were induced by a combination of levodopa and tranylcypromine. These hypertensive reactions were inhibited by carbidopa, indicating that they are mediated at the periphery. Very small doses of levodopa induced an improvement in parkinsonism when patients were concomitantly taking carbidopa and tranylcypromine, but adverse reactions were prominent.