Premium
EPEG, a new antineoplastic epipodophyllotoxin
Author(s) -
Creaven Patrick J.,
Allen Larry M.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975182221
Subject(s) - volume of distribution , chemistry , pharmacology , pharmacokinetics , chromatography , medicine
Nine patients were studied with tritium‐labeled EPEG, a new epipodophyllotoxin antineoplastic agent. Four patients received 220 and 5 received 290 mg/sq m body surface area intravenously in 500 ml in 1 hr. Postinfusion plasma decay was biphasic with mean values for the parameters at 220 mg/sq m, A, 25.8 µglml; B, 3.35 µg/ml; α, 0.50 hr −1 ; β, 0.074 hr −1 , and mean values at 290 mg/sq. m, A, 33.7 µg/ml; B, 4.35 µg/ml; α, 0.36 hr −1 ; ², 0.066 hr −1 , Mean volume of distribution was 32.07% of body weight. Urinary recovery was 43.5%, of which 66.8% was unchanged drug. Penetration of drug into the cerebrospinal fluid was poor. The results indicate that both renal excretion and metabolism are important for elimination of the drug.