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Bioavailability of oral dexamethasone
Author(s) -
Duggan D. E.,
Yeh K. C.,
Matalia N.,
Ditzler C. A.,
McMahon F. G.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975182205
Subject(s) - elixir (programming language) , bioavailability , pharmacokinetics , dexamethasone , pharmacology , plasma concentration , medicine , chemistry , chromatography , computer science , programming language
Bioavailabilities of dexamethasone tablets and elixir in man were evaluated by each of 3 model‐independent methods of pharmacokinetic analysis employing plasma and urinary values as determined by radioimmune assay. There were no significant differences among the results determined by the 3 methods nor between the respective availabilities of the !Wo formulations; the latter averaged 82.6 ± 17.7% for the elixir formulation and 78.0 ± 12.1% for tablets.