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Folie acid dosage for chronic hemodialysis patients
Author(s) -
Skoutakis Vasilios A.,
Acchiardo Sergio R.,
Meyer Marvin C.,
Hateh Fred E.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975182200
Subject(s) - folic acid , hemodialysis , medicine , dialysis , crossover study , pharmacology , placebo , alternative medicine , pathology
The doses of folic acid, neeessary to avoid folic acid deficiency in patients being maintained on hemodialysis, have been estimated to be between land 5 mg daily. To more precisely define an adequate dose of folic acid, 6 anephric patients were studied. The patients were maintained on hemodialysis and received, in a crossover fashion, 1 mg and 5 mg of folic acid for 3 wk. In a second crossover study, 3 anephric patients were first maintained on 0 and then on 1 mg of folic acid after each dialysis for 3‐wk periods. Pre‐ and postdialysis folic acid blood levels were measured and dialyzer clearances of folic acid were determined. The results of this study support the conclusion of the Food and Drug Administration report suggesting that daily doses of 1 mg of folic acid are adequate to sustain therapeutic folate levels. The data further indicate that the administration of 1 mg of folic acid after each dialysis, rather than 1 mg of folic acid daily, can provide adequate folate.