Premium
Effects of tricyclic antidepressants on drug metabolism
Author(s) -
Pond Susan M.,
Graham Garry G.,
Birkett Donald J.,
Wade Denis N.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975182191
Subject(s) - nortriptyline , amitriptyline , tolbutamide , tricyclic , bioavailability , pharmacology , phenytoin , drug , pharmacokinetics , carbamazepine , plasma levels , metabolism , chemistry , plasma concentration , warfarin , drug metabolism , half life , medicine , insulin , epilepsy , psychiatry , atrial fibrillation
The effects of chronic treatment with amitriptyline and nortriptyline on the elimination from plasma of warfarin, dicumarol, phenytoin, and tolbutamide were examined in man. No alteration of plasma half‐life of warfarin, phenytoin, or tolbutamide was observed following dosage with the tricyclic antidepressants used. There was no consistent effect on the metabolism of dicumarol following treatment with amitriptyline or nortriptyline although the bioavailability of dicumarol appeared to be increased. In some subjects, this increased bioavailability was associated with significant prolongation of the plasma half‐life of dicumarol due to its dose‐dependent kinetics.