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Interactions in man of delta‐9‐tetrahydrocannabinol; II. Cannabinol and cannabidiol
Author(s) -
Hollister Leo E.,
Gillespie Hampton
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197518180
Subject(s) - cannabidiol , cannabinol , delta 9 tetrahydrocannabinol , tetrahydrocannabinol , chemistry , cannabis , pharmacology , medicine , cannabinoid , psychiatry , receptor
Oral doses of delta‐9‐tetrahydrocannabinol (THC) 20 mg, combined with placebo or with 40 mg doses of cannabinol (CBN) and cannabidiol (CBD), were given to volunteers. The combination of THC with CBN produced no detectable changes in the quality, intensity, or duration of the effects of THC alone. The THC‐CBD combination tended to delay onset and prolong effects of THC, while making them somewhat more intense. Even this interactive effect was slight, providing no reason to abandon the current practice of basing doses of marihuana for clinical studies solely on THC content.