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Electrophysiologic effects of glucagon on human cardiac muscle
Author(s) -
Prasad Kailash
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197518122
Subject(s) - glucagon , effective refractory period , refractory period , contraction (grammar) , medicine , papillary muscle , endocrinology , nerve conduction velocity , cardiology , cardiac muscle , chemistry , hormone
The effects of glucagon (5, 10, and 40 µg/ml) on the amplitude and duration of action potential, effective refractory period, dv Idt of phase 0 of action potential, membrane responsiveness, and contraction in human papillary muscles obtained from patients undergoing corrective open heart surgery were investigated. Glucagon, in none of the concentrations, produced any significant change in the amplitude and duration of action potential, or in force of contraction. Shortening of the effective refractory period was not significant. Glucagon enhanced the conduction and the membrane responsiveness by increasing the dvldt of phase 0 of action potential and a shift of curve to the left. It is suggested that the latter properties of glucagon would abolish the “re‐entrant” type of cardiac arrhythmias produced by cardiac glycosides or other drugs that initiate and perpetuate arrhythmias due to altered conduction.