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Controlled trial of propranolol in intermittent claudication
Author(s) -
Shoulson Ira,
Chase Thomas N.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975175616
Subject(s) - fenfluramine , serotonergic , homovanillic acid , medicine , probenecid , serotonin , dopaminergic , endocrinology , dopamine , appetite , cerebrospinal fluid , anesthesia , receptor
A double‐blind trial of orally administered fenfluramine was conducted in 7 non‐obese adults with various neurological disorders. Caloric intake and body weight fell significantly after 8 days of treatment although there was no definite change in appetite ratings. Average central turnover of serotonin, as estimated by the cerebrospinal fluid (CSF) accumulation of 5‐hydroxyindoleacetic acid (5‐HIAA) during probenecid loading, decreased by 66%. No significant change in homovanillic acid, the major dopamine product, was apparent. The results support the contention that the effect of fenfluramine on human dietary intake may be mediated by alterations in serotonergic rather than dopaminergic mechanisms.