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Pharmacokinetic studies of tolmetin in man
Author(s) -
Selley M. L.,
Glass J.,
Triggs E. J.,
Thomas J.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975175599
Subject(s) - pharmacokinetics , volume of distribution , elimination rate constant , rheumatoid arthritis , dosing , oral administration , pharmacology , distribution (mathematics) , medicine , distribution volume , absorption (acoustics) , half life , plasma concentration , mathematics , mathematical analysis , physics , acoustics
The pharmacokinetics of the new anti‐inflammatory agent tolmetin have been studied after its oral administration to normal subjects and to patients with rheumatoid arthritis. Plasma concentration‐time data were fitted to a one‐compartment open model. Following single oral doses, no basic differences in rates of drug absorption and elimination were found between normal subjects and arthritic patients. For the 12 subjects studied, the overall mean elimination rate constant was 0.839 hr ‒1 , corresponding to a plasma half‐life of 0.83 hr. The drug was rapidly absorbed and had a mean apparent volume of distribution of 0.098 1/kg. Plasma levels and pharmacokinetic parameters of tolmetin in arthritic patients after multiple dosing were similar to those after a single dose.