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Comparative respiratory depression of tilidine and morphine
Author(s) -
Romagnoli Alexander,
Keats Arthur S.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975175523
Subject(s) - morphine , medicine , anesthesia , depression (economics) , (+) naloxone , nausea , respiratory system , vomiting , opioid , receptor , economics , macroeconomics
Respiratory depression induced by tilidine was compared with that of morphine in a crossover study in 6 healthy subjects. Increments of tilidine, 150 mg/70 kg, and morphine, 10 mg/70 kg, were given intravenously and displacement of each subject's CO 2 response curve was measured after each dose increment. Both tilidine and morphine caused dose‐related displacement of the CO 2 response curves to the right. Approximately 80 to 120 mg of tilidine can be expected to induce the respiratory depresssion of morphine, 10 mg, when given intravenously. Subjective effects after tilidine were qualitatively similar to those of morphine but were of longer duration with nausea and vomiting more frequent. The respiratory depression of both drugs was effectively antagonized by naloxone.