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Influence of diet and fluid on bioavailability of theophylline
Author(s) -
Welling P. G.,
Lyons L. L.,
Craig W. A.,
Trochta G. A.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975174475
Subject(s) - dosing , bioavailability , theophylline , meal , absorption (acoustics) , pharmacokinetics , chemistry , pharmacology , dosage form , stomach , medicine , food science , biochemistry , physics , acoustics
The influence of various test meals, and of fluid volumes, on the bioavailability of theophylline from asolid dosage form has been studied in healthy male volunteers. Absorption of drug was faster after dosing immediately following a high protein meal than after a high fat or a high carbohydrate meal. Absorption from a solution was faster than from asolid dosage form in all treatments; areas under serum level time curves after dosing were also significantly higher up to 12 hr. Areas up to 12 hr after dosing also tended to be higher after the high protein meal and after dosing with 500 ml water on an empty stomach than after other solid dose treatments.