Premium
Effect of tolamolol and propranolol on exercise heart rate and angina
Author(s) -
Aronow Wilbert S.,
Spivack Nordy,
Laverty Wayne,
Warren Max
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975174379
Subject(s) - propranolol , heart rate , angina , medicine , blood pressure , cardiology , anesthesia , rate pressure product , saline , myocardial infarction
Fifteen patients with angina pectoris participated in a double‐blind study evaluating the effect of intravenous saline, 10 mg of intravenous tolamolol, 20 mg of intravenous tolamolol, and 10 mg of intravenous propranolol on resting and exercise heart rate and on exercise time until angina. Twenty mg of tolamolol and 10 mg of propranolol caused a similar decrease in mean resting heart rate, heart rate after a similar amount of exercise, heart rate at angina, resting product of systolic blood pressure times heart rate, and product of systolic blood pressure tim es heart rate at angina and were, therefore, judged equipotent. Tolamolol, 10 and 20 mg, and propranolol, 10 mg, were not followed by a significant change in mean exercise duration until angina, but there was a 25% increase in exercise time until angina in 4 of 15 patients (27%) after 10 mg of propranolol and in 3 of 15 patients (20%) after 20 mg of tolamolol.