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Comparison of amikacin and gentamicin
Author(s) -
Klastersky Jean,
Odio Wobin,
Hensgens Colette
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975173348
Subject(s) - amikacin , gentamicin , microbiology and biotechnology , chemistry , proteus , escherichia coli , serial dilution , antibiotics , biology , medicine , biochemistry , alternative medicine , pathology , gene
The sensitivity to gentamicin (G) and to amikacin (A) of 25 strains of Escherichia coli (EC), 25 Klebsiella sp, (K), 25 Proteus and Providence sp. (PP), and 25 Ps. aeruginosa (PA) were tested in vitro by the disc method, by the inocula‐replicating method, and by a tube dilution technique using 10 5 microorganisms/ml. Bactericidal concentrations active on 50% and 90% of the strains were 1.5 and 4.5 µg/ml for EC, 3 and 3 µg/ml for K, 1.5 and 3 µg/ml for pp, and 3 and 3 µg/ml for PA. Resistance to killing by 12 µg/ml of G was foundfor 16 strains (1 EC, 9 K, 4 PP, and 2 PAY but only 5 strains were also resistant to 12 µg/ml of A. Conversely, 4 strains (1 EC, 1 pp, and 2 PAY were resistant to 12 µg/ml of A but were killed by 6 µg/ml of G or even less. G (1.5 mg/kg) and A (5 mg/kg) were administered to 5 volunteers in a crossover fashion. The mean bactericidal activity of the sera obtained at 1 hr after the injection of G and A was, respectively, % and % for ED, % and 1/8 for K, V2 and V2 for PP, and V2 and V2 for P A. Sera obtained in A ‐treated patients killed at a dilution of Va, 8 strains of ED, 17 K, 1 PP, and 0 PA; at that dilution sera from G‐treated patients killed 5 ED, 9 K, 0 P, and 0 PA. The main advantage of A over G might be the absence of cross‐resistance between A and G for particular pathogens.