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Pharmacokinetics of sulbenicillin, a new broad‐spectrum semisynthetic penicillin
Author(s) -
Hansen Ib,
Jacobsen Erik,
Weis Jan
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975173339
Subject(s) - penicillin , broad spectrum , medicine , pharmacokinetics , pharmacology , antibiotics , chemistry , microbiology and biotechnology , biology , combinatorial chemistry
In a pharmacokinetic study on a new semisynthetic penicillin, α‐sulfobenzylpenicillin, sulbenicillin, serum level, serum half‐life, apparent distribution volume, renal clearance, urinary excretion, and metabolism were determined after a 4‐gm intravenous dose and compared to that of carbenicillin in 5 patients with normal renal function. In the case of sulbenicillin, the mean serum concentration at 1 hr was 157 ± 25 µg/ml, the mean serum half‐life was 70 ± 10 min, the renal clearance was 95 ± 25 ml/min, and the total urinary recovery after 24 hr was about 80% of the dose. The only metabolite detected in the urine was the penicilloic acid derivative, in an amount usually less than 5% of the dose. Serum values, serum half‐life, renal clearances, and excretion pattern did not differ significantly from that of carbenicillin. In 8 patients with decreased renal function (creatinine clearance < 50 ml/min) there was an inverse correlation between creatinine clearance and serum half‐life.