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Pharmacokinetics and metabolism of digoxin‐ and β‐methyl‐digoxin‐12α‐ 3 H in patients with acute hepatitis
Author(s) -
Zilly W.,
Richter E.,
Rietbrock N.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975173302
Subject(s) - digoxin , pharmacokinetics , medicine , pharmacology , acute hepatitis , hepatitis , demethylation , hepatitis a virus , chemistry , virology , heart failure , biochemistry , virus , gene expression , dna methylation , gene
Pharmacokinetics and metabolism of digoxin and β‐methyldigoxin have been studied in patients with acute hepatitis after intravenous administration of both 3 H‐labeled glycosides. In contrast to digoxin, the rate of decline of radioactivity after administration of β‐methyldigoxin was significantly retarded in patients with acute hepatitis. The increase in plasma concentration after β‐methyldigoxin to patients with acute hepatitis is probably related to decreased demethylation.