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Etorphine in man. I. Subjective effects and suppression of morphine abstinence
Author(s) -
Jasinski Donald R.,
Griffith John D.,
Carr Carter B.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975173267
Subject(s) - etorphine , abstinence , morphine , anesthesia , medicine , psychology , opioid , psychiatry , (+) naloxone , receptor
The effects of etorphine, a potent morphine‐like drug, were qualitatively and quantitatively compared to those of morphine. In nondependent subjects, etorphine in doses of 0.025, a .050, and 0.100 mg produced pupillary constriction and morphine‐like subjective effects and euphoria. Etorphine was 500 times as potent as morphine, with a very rapid onset and short duration of action. In morphine‐dependent subjects, etorphine suppressed abstinence but for a shorter period than morphine. These studies indicate that in man etorphine is a morphine‐like drug with a high abuse potential.