Premium
Heparin half‐life in normal and impaired renal function
Author(s) -
Ignoffo Robert J.,
Perry Paul J.,
Blachly Paul H.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975172249
Subject(s) - heparin , half life , elimination rate constant , impaired renal function , renal function , medicine , endocrinology , pharmacokinetics , volume of distribution
I read with great interest the article by Dr. Paul Perry and associates entitled “Heparin half‐life in normal and impaired renal function,” which appeared in the September, 1974, issue of the JOURNAL. It appears that the heparin infusion rate equation as derived by Dr. Perry is not substantiated by the half‐life values obtained from the study patients. A half‐life of 37 min is reported for normal patients given a dose of heparin sufficient to produce a plasma concentration of 0.6 U/ml. A half‐life of 37 min can be converted to a plasma elimination constant of 1.13 hr −1 .