Premium
Antiarrhythmic activity of four pteridine compounds in ouabain intoxication
Author(s) -
Yeh Billy K.,
Francis James S.,
Gosselin Arthur J.,
Elias Richard A.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1975172141
Subject(s) - ouabain , triamterene , pteridine , diuretic , ventricular tachycardia , tachycardia , carboxamide , pharmacology , chemistry , pentobarbital , medicine , sodium , stereochemistry , biochemistry , organic chemistry , blood pressure , hydrochlorothiazide , enzyme
The antiarrhythmic effects of 4 pteridine analogues, 2 of which are potassium‐sparing diuretics, triamterene (2, 4, 7‐triamino‐6‐phenylpteridine) and [2‐phenyl‐4, 7 diaminopteridine‐6‐(N‐diethylaminoethyl) carboxamide] and 2 of which have no diuretic effects [2‐phenyl‐4, 7‐diaminopteridine‐6‐(N‐2‐hydroxyethyl) carboxamide] and [2‐phenyl‐4, 7 diaminopteridine‐6‐(N‐dimethylaminopropyl) carboxamide], on ouabain‐induced ventricular tachycardia in intact pentobarbital‐anesthetized dogs were investigated. Ouabain was given as a continuous infusion 2 µg/kg/min intravenously until 5 min after the onset of a sustained ventricular tachycardia. It was found that both 6‐(N‐dimethylaminopropyl) and 6‐(N‐diethylaminoethyl) carboxamide derivates of the pteridine had a significant protective effect against ouabain‐induced ventricular tachycardia in dogs that had been pretreated with a dose of 5 mg/kg intravenously. At this dose the 2 pteridine compounds with diuretic activity exhibited a transient antiarrhythmic effect in abolishing the ouabain‐induced ventricular tachycardia while those without diuretic properties failed to suppress the ventricular tachycardia.