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Hemodialysis in an infant with propoxyphene intoxication
Author(s) -
Mauer S. Michael,
Paxson Charles L.,
Hartizsch Barry,
Buselmeier Theodore J.,
Kjellstrand Carl M.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197517188
Subject(s) - propoxyphene , medicine , dialysis , hemodialysis , blood urea nitrogen , intensive care medicine , hyperkalemia , anesthesia , kidney , analgesic
A 10‐month‐old infant was treated with intensive supportive care and hemodialysis for severe propoxyphene intoxication. Dialysis clearance studies demonstrated that propoxyphene was removedfrom the serum at approximately 50% of the rate of blood urea nitrogen removal. Possibly because of tissue binding of the drug, the absolute quantity of propoxyphene removed by dialysis was small. The child survived the acute episode of intoxication but died of pulmonary complications several days later. The role of dialysis in propoxyphene intoxication remains to be established.