Premium
Determination of propoxyphene and norpropoxyphene by chemical ionization mass fragmentography
Author(s) -
Walen Robert L.,
Ziege Edgar A.,
Gruber Charles M.
Publication year - 1975
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197517115
Subject(s) - propoxyphene , chemistry , chromatography , mass spectrometry , metabolite , gas chromatography , gas chromatography–mass spectrometry , deuterium , pharmacology , analgesic , medicine , biochemistry , physics , quantum mechanics
The development of a gas‐liquid chromatographic method 9 for the measurement of propoxyphene (Darvon) in plasma and extension of this technique to norpropoxyphene 6, 8 has led to the examination of the kinetics of the drug and its primary metabolite. 2, 5, 6, 8, 10 Calculations indicated that a considerable “first pass effect” 3 influences drug plasma levels. Low assay sensitivity has prevented plasma level measurement for the extended periods of time necessary to establish terminal plasma concentrations. 7