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Differential effects of propranolol on heart rate and plasma renin activity in patients treated with minoxidil
Author(s) -
Velasco M.,
Malley K. O,
Robie N. W.,
Wells J.,
Israili Z. H.,
McNay J. L.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt19741661031
Subject(s) - propranolol , minoxidil , heart rate , concomitant , plasma renin activity , medicine , blood pressure , endocrinology , chemistry , pharmacology , renin–angiotensin system
The relationship between PPC and its effect on minoxidil‐induced increases in PHA and heart rate was examined in 9 patients with essential hypertension. Concomitant with the minoxidil‐induced depression of mean arterial pressure (30.7 ± 3.5 mm Hg, mean ± SEM), heart rate increased from 79.1 ± 3.0 to 100.4 ± 4.6 BPM, and PHA increased from 1.12 ± 0.28 to 8.58 ± 2.83 nglmllhr. Addition of propranolol to minoxidil caused a decrease in heart rate in proportion to log PPC: Δ heart rate = 1.1 − 12.8 log PPC (r, 0.59, p < 0.005) The relationship between PPC and the reduction in PHA was more complex. While a major reduction in PHA was observed at PPC in the range 20 to 60 nglmllhr, there was no consistent effect on PHA at higher PPC. Therefore, maximum antagonism of adrenergicaUy mediated increases in PHA is produced by much lower concentrations of propranolol than maximum suppression of adrenergically mediated increases in heart rate.