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Comparison of one‐ and six‐day urinary digoxin excretion in single‐dose bioavailability studies
Author(s) -
Greenblatt David J.,
Duhme David W.,
Weser Jan Koch,
Smith Thomas W.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974165part1813
Subject(s) - bioavailability , digoxin , urine , medicine , pharmacokinetics , urinary system , pharmacology , oral administration , excretion , heart failure
Eight healthy males received oral and parenteral digoxin by 10 modes of administration in a total of 91 single‐dose, multicrossover bioavailability trials. One‐ and six‐day urinary excretions of digoxin were compared as measures of bioavailability. One‐ and six‐day eXCfetions were highly correlated (r = 0.94). Overall variability in the two measures was nearly identical. Thus 24 hours of urine collection is sufficient for single‐dose studies of digoxin bioavailability.