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Isoproterenol metabolism in children after intravenous administration
Author(s) -
Kadar D.,
Tang H. Y.,
Conn A. W.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974165part1789
Subject(s) - urine , metabolism , drug , serum concentration , drug metabolism , medicine , urinary system , pharmacokinetics , endocrinology , pharmacology , chemistry
The metabolism of intravenously administered isoproterenol was investigated in children with severe brain damage between the ages of 6 and 16, using isoproterenol‐7‐ 3 H. The serum concentration of .9H declined in a biphasic manner with the half‐lives of 2.5 to 5 minutes estimated from the rapid first phase and 3 to 7 hours estimated from the second slower phase. The drug is rapidly metabolized and after 15 to 30 minutes less than 10% of the .1H in the serum represents unchanged drug and after 1 hour less than 3%. The metabolites found in the serum and urine are free and con;ugated 3‐0‐methylisoproterenol, con;ugated isoproterenol, and an unknown substance that is excreted mainly in the bile. About 4% of the dose was eliminated in the urine in 5 minutes, 60% in 6 hours, and over 90% in 24 hours. Less than 15% of the urinary radioactivity represented unchanged drug, and most of that was eliminated during the first 2 hours.