Premium
Heparin half‐life in normal and impaired renal function
Author(s) -
Perry Paul J.,
Herron George R.,
King James C.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974163part1514
Subject(s) - medicine , heparin , volume of distribution , chronic renal failure , anticoagulant , pharmacokinetics , renal function , urology , half life , population , anesthesia , environmental health
The half‐life of heparin was calculated in persons with normal renal function and in patients in chronic renal failure. Intravenous heparin, 0.3 and 0.6 U/ml of blood volume, was administered. The anticoagulant half‐life of heparin was found to be dose‐related. The normal renal function group gave a mean anticoagulant half‐life of 36.S minutes for the 0.6 U/ml dose and 22.7 minutes for the 0.3 U/ml dose. The chronic renal failure population had a mean half‐life of 47.5 minutes for the 0.6 U/ml dose and a mean half‐life of 32.6 minutes for the 0.3 U/ml dose. By use of the equations of first‐order pharmacokinetics, a heparin dosage schedule was derived through which anticoagulation of patients can proceed by means of constant infusion of the drug. The schedule not only is applicable to patients in renal failure but also may be used in heparinization of patients with normal renal function.