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Pharmacokinetics of thiothixene in man
Author(s) -
Hobbs Donald C.,
Welch Willard M.,
Short Marvin J.,
Moody William A.,
van der Velde C. D.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974163part1473
Subject(s) - pharmacokinetics , plasma concentration , pharmacology , drug , therapeutic index , medicine , plasma levels , chemistry
A new specific and sensitive assay for thiothixene, using mass fragmentography, has been developed and used to measure plasma concentrations in psychotic patients on long‐term therapy. Drug plasma concentrations reach an early peak following an oral dose and decline slowly thereafter. Despite considerable differences in doses, peak plasma concentrations fall within a relatively narrow range, indicating that, during earlier ad;ustments of dose to achieve therapeutic control, optimum plasma concentrations were also being achieved.