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Absorption and clearance of secobarbital, heptabarbital, methaqualone, and ethinamate
Author(s) -
Clifford John M.,
Cookson James H.,
Wickham Phyllis E.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974162376
Subject(s) - methaqualone , secobarbital , plasma levels , clearance , pharmacokinetics , chemistry , anesthesia , medicine , chromatography , pentobarbital , urology
The absorption and clearance of secobarbital, heptabarbital, methaqualone, and ethinamate were studied by measurements of blood and plasma drug levels after single oral dosage in the therapeutic range to nonfasting sub;ects. Determinations of blood and plasma levels were carried out to the limits of sensitivity of the gas‐liquid chromatographic determination steps. The mean maximum plasma level of ethinamate was observed after 1 hour; that of methaqualone occurred after 2 hours; the mean maximum blood level of secobarbital was found after 3 hours, whereas that of heptabarbital was not observed until the sixth hour. Secobarbital was cleared slowly from the blood (the calculated half‐life was 28.9 hours); heptabarbital was faster (half‐life, 9.7 hours), and the half‐life of ethinamate was calculated as 2.3 hours. Methaqualone plasma levels decayed in a biphasic manner; the half‐life of the fast component was calculated as 0.9 hour and the slow one as 16 hours. Secobarbital, heptabarbital, and methaqualone could all be detected in the body 24 hours after they had been given.