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Delta‐9‐tetrahydrocannabinol and glucose tolerance
Author(s) -
Hollister Leo E.,
Reaven Gerald M.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974162297
Subject(s) - delta 9 tetrahydrocannabinol , δ9 tetrahydrocannabinol , impaired glucose tolerance , tetrahydrocannabinol , medicine , diabetes mellitus , drug tolerance , pharmacology , type 2 diabetes , endocrinology , cannabinoid , receptor
Intravenous doses of 6 mg of delta‐9‐tetrahydrocannabinol (THC) produced moderately severe marihuana intoxications. Glucose tolerance was impaired, and this deterioration of glucose tolerance was associated with increased plasma levels of growth hormone. Although large doses of marihuana might aggravate diabetes, the rarity of this phenomenon in clinical practice may be due to the lower doses of THC used socially or development of tolerance to this specific pharmacologic effect.