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From animals to man: Metabolie eonsiderations
Author(s) -
Conney A. H.,
Coutinho C.,
Koechlin B.,
Swarm R.,
Cheripko J. A.,
Impellizzeri C.,
Baruth H.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974161part2176
Subject(s) - drug metabolism , drug , pharmacology , medicine , biology , physiology
Metabolie studies that are helptul tor the extrapolation of animal data trom one species to another, and from animals to man, include the investigation of speeies differenees in rates and pathways of drug metabolism and the determination of whether or not plasma eoneentrations of a drug and/or its metabolites are eorrelated with the drug's pharmaeologie aetion or toxieity. Individual differenees in the metabolism of a new drug in man should also be eonsidered, and the dose of the drug should be adjusted to the metabolie eapaeity of the individual. Metabolie studies early in the investigation of an experimental anti‐inflammatory eompound are presented as an example of how metabolie studies may be helpful during the development of a new drtlg.