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Propranolol enhancement of hypoglycemic sweating
Author(s) -
Molnar George W.,
Read Raymond C.,
Wright F. Elvis
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974155490
Subject(s) - propranolol , hypoglycemia , endocrinology , epinephrine , medicine , sweat , insulin , chemistry
Oral propranolol doubled sweating during insulin‐induced hypoglycemia in 19 men. Two of 7 hypoglycemic patients studied with propranolol alone did not sweat, establishing that propranolol does not initiate sweating either by discharges from the hypothalamus or by direct action on sweat glands. Therefore, propranolol enhances hypoglycemic sweating by either blocking a beta adrenergic agent (perhaps epinephrine) that inhibits secretion or by potentiating the discharge of impulses by glucopenic neurones of the hypothalamus (possibly by competitive displacement of membrane calcium).