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Effects of in vitro aspirin on blood platelets of gastrointestinal bleeders
Author(s) -
Donald G. Mills,
Ivan T. Borda,
Richard B. Philp,
Cheryl Eldridge
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974152187
Subject(s) - aspirin , platelet , gastrointestinal tract , adenosine diphosphate , platelet aggregation , in vitro , medicine , gastroenterology , ingestion , adenosine , chemistry , biochemistry
Collagen and adenosine diphosphate (ADP)‐induced platelet aggregation and the inhibitory effects of in vitro aspirin were studied in 11 subjects (Group I) having gastrointestinal hemorrhage within 96 hours at taking aspirin, II (Group II) with similar hemorrhage not associated with recent aspirin ingestion, and 11 hospitalized control subjects (Group III). Platelets at Groups I and II were significantly more sensitive to ADP aggregation than those of Group III (p < 0.005). Aspirin caused significantly greater inhibition of collagen aggregation in Group I than in either Group II (p < 0.005) or Group III (p < 0.02). Three of the II nonaspirin bleeders lacked the second phase of ADP aggregation. These data support the contention that individuals with defective platelet function are more susceptible to hemorrhage following mucosal erosion of the gastrointestinal tract and suggest that some individuals may have platelets that are intrinsically more sensitive to aspirin.