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Orthohydroxyhippuric (salicyluric) acid—its physiologic and clinical significance
Author(s) -
Altschule Mark D.,
Hegedus Zoltan L.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1974152111
Subject(s) - salicylic acid , benzoic acid , hippuric acid , excretion , chemistry , metabolite , ingestion , gentisic acid , urine , sodium salicylate , pharmacology , medicine , organic chemistry , biochemistry
Orthohydroxybenzoic acid was given the name salicylic acid because it was made in 1838 from a product of willow bark ( Salix alba ). About fifty years later salicylates became established as useful in the treatment of rheumatic fever. In the interval orthohydroxyhippuric acid was discovered and was named salicyluric acid . The fact that ingesting benzoic acid led to the excretion of hippuric acid led Bertagnini 10 in 1856 to look successfully for salicyluric acid in the urine after the ingestion of salicylate. For almost a hundred years thereafter orthohydroxyhippuric acid was thought of almost entirely as a metabolite of salicylate. A large amount of research was done on the formation and excretion of orthohydroxyhippuric acid in relation to salicylate therapy. Orthohydroxyhippuric acid also became important in the chemical industry, and much study has been devoted to its synthesis and its properties. 12 , 28