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Arterial blood levels of fluorocarbons in asthmatic patients following use of pressurized aerosols
Author(s) -
Dollery C. T.,
Williams Faith M.,
Draffan G. H.,
Wise G.,
Sahyoun H.,
Paterson J. W.,
Walker S. R.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197415159
Subject(s) - liter , inhalation , arterial blood , fluorocarbon , epinephrine , inhaler , aerosol , chemistry , anesthesia , medicine , asthma , organic chemistry
The levels of fluorocarbon‐11 and fluorocarbon‐12 (F‐11, CCl 3 F; F‐12, CCl 2 F 2 ) have been measured in arterial blood of 8 asthmatics after using an aerosol inhaler. Following two puffs with a 30 second interval, peak arterial plasma levels ranged from 0.53 to 3.1 µg per milliliter (F‐11) and 0.2 to 3.13 µg per milliliter (F‐12); folloWing a single puff peak levels were 0.26 to 2.0 J.lg per milliliter (F‐11) and 0 to 2.3 J.lg per milliliter (F‐12). The peak level was achieved 10 to 20 seconds after the inhalation, followed by a rapid fall in arterial level. The measured levels have been compared with predicted values using a computer model. This model has been used to predict the myocardial concentration in man from the measured arterial levels. Except with grossly excessive use of an aerosol inhaler in a short period of time, the predicted myocardial concentrations of fluorocarbon in man are much less than the levels shown to sensitize the heart of conscious normal dogs to epinephrine.