Premium
N‐oxidation of a tertiary amine (N,N‐dimethylaniline) by human fetal liver microsomes
Author(s) -
Rane Anders
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197415132
Subject(s) - tertiary amine , microsome , chemistry , amine gas treating , microsoma , cytochrome , dimethylaniline , nicotinamide adenine dinucleotide phosphate , nicotinamide , fetus , oxygenation , biochemistry , phosphate , organic chemistry , medicine , enzyme , biology , pregnancy , oxidase test , genetics
Human fetal liver microsomes were shown to catalyze the N‐oxidation of a tertiary amine, N,N‐dimethylaniline. The reaction was dependent on reduced nicotinamide adenine dinucleotide phosphate but was not inhibited by CO. The results are in agreement with those obtained from studies on N‐oxygenation of secondary and tertiary amines by animal liver microsomes, which show that this reaction appears to proceed independently of cytochrome P‐450. The findings are of interest from a toxicologic and teratologic point of view since the N‐oxygenation of some amine drugs may lead to the formation of potentiaUy toxic metabolites.