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Interactions in man of delta‐9‐tetrahydrocannabinol I. Alphamethylparatyrosine
Author(s) -
Hollister Leo E.
Publication year - 1974
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt197415118
Subject(s) - delta 9 tetrahydrocannabinol , serotonin , chemistry , delta , acetylcholine , catecholamine , pharmacology , medicine , endocrinology , biochemistry , cannabinoid , receptor , engineering , aerospace engineering
The interaction of alphamethylparatyrosine (AMPT) and delta‐9‐tetra‐hydrocannabinol (THe) was studied in three separate experiments, two giving THe orally, one administering it intravenously. Pretreatment with doses of 2.0 to 4.0 gm of AMPT produced no major qualitative or quantitative change in the effects of THe. Some accentuation of the total intensity of THe was apparent in each of these experiments, but one could not be certain whether this difference was due to additive pharmacologic effects or diminished catecholamine concentrations in brain. It would appear that mental effects of THe are not mediated primarily through catecholamines, but rather by the balance between the concentrations of these amines and others, such as acetylcholine or serotonin.