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Oxprenolol: Long‐term effects in arterial hypertension
Author(s) -
Gysling Etzel,
Regoli Domenico
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973146995
Subject(s) - oxprenolol , supine position , blood pressure , medicine , heart rate , essential hypertension , cardiology , diastole , anesthesia
Oxprenolol, a new beta adrenergic blocking drug, was used as the sole antihypertensive agent for a minimum of 14 weeks in 20 patients with mild to moderate essential hypertension. The results demonstrate a definite, but not prominent, antihypertensive activity of this drug. Oxprenolol does not lower the blood pressure sufficiently in an unselected group of patients, but its effect is clinically satisfactory and well tolerated in some cases of mild “borderline” hypertension. In the latter, low doses of oxprenolol influence equally the systolic and diastolic blood pressure in both supine and standing position. The decrease in heart rate is relatively small. No maior side effects were noted.