Premium
Deoxythioguanosine and thioguanine
Author(s) -
LePage G. A.,
Gottlieb J. A.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973146966
Subject(s) - dna , rna , toxicity , dna synthesis , chemistry , bone marrow , microbiology and biotechnology , biochemistry , biology , medicine , pathology , gene , organic chemistry
Incorporation of 6‐thioguanine (TG) and β‐2'‐deoxythioguanosine (β‐TGdR) into the DNA and RNA of human bone marrow and tumors were measured. The ratio of incorporation into DNA vs that into RNA was taken as an indication of the extent to which β‐TGdR was a direct precursor for DNA synthesis without conversion to TG. Incorporation into DNA has been found to correlate with lethal effects of the cells. The data support the concept that β‐TGdR was superior to TG in obtaining incorporation into DNA and to a considerable extent was a direct DNA precursor. Clinical observation also indicates that β‐TGdR acts as a direct precursor of DNA. In 7 of 18 patients receiving β‐TGdR, skin toxicity was observed. In 38 patients receiving TG, no such skin toxicity was observed.