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Formation of a 16,17‐trans‐glycolic metabolite from a 16‐dehydro‐androgen in human fetal liver microsomes
Author(s) -
Rane Anders,
Gustafsson Jan-Åke
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973145833
Subject(s) - microsome , fetus , chemistry , metabolite , epoxide , human liver , double bond , substrate (aquarium) , enzyme , androgen , stereochemistry , biochemistry , organic chemistry , hormone , biology , catalysis , pregnancy , ecology , genetics
This study aimed to investigate if the human fetus can form epoxides during the oxidation ot double bonds. Indirect evidence for this was obtained using 4,16‐androstadien‐3‐one as substrate of the liver microsomal drug oxidation enzyme system. Human fetal liver microsomes were shown to catalyze the formation of the corresponding 16,17‐glycol, a reaction that is thought to proceed via an intermediary 16,17‐epoxide. The findings may imply that the human fetus is also capable of forming epoxides from certain drugs that contain double bonds.