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Inhibition by lithium of prostaglandin E 1 and norepinephrine effects on cyclic adenosine monophosphate production in human platelets
Author(s) -
Murphy Dennis L.,
Donnelly Cynthia,
Moskowitz Jay
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973145810
Subject(s) - lithium (medication) , lithium chloride , medicine , endocrinology , prostaglandin e1 , chemistry , adenosine , cyclic adenosine monophosphate , in vivo , platelet , lithium carbonate , stimulation , prostaglandin e2 , norepinephrine , prostaglandin e , in vitro , antagonism , prostaglandin , biochemistry , biology , dopamine , receptor , inorganic chemistry , ion , microbiology and biotechnology , organic chemistry , ionic bonding
Prostaglandin E 1 (PGE 1 )‐stimulated cyclic adenosine monophosphate (AMP) production in human platelets is inhibited during treatment with lithium carbonate under ordinary clinical conditions. In acute experiments in vitro, greater concentrations of lithium chloride are required to produce a similar inhibition of PGE 1 ‐stimulated cyclic AMP production. Antagonism by norepinephrine of the PGE 1 stimulation effect on cyclic AMP production is also inhibited by lithium in vivo and in vitro. It is suggested that these and possibly other hormonal blocking effects of lithium may be relevant to its antimanic efficacy and to other clinical effects of this drug.