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Changes in fetal steroid metabolism with age
Author(s) -
Villee Dorothy B.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973144part2705
Subject(s) - fetus , endocrinology , medicine , hormone , adrenal gland , biology , gestation , steroid hormone , steroid , pregnancy , genetics
As gestation proceeds enzymes develop or are activated. Some of the enzymes catalyze steps in the synthesis of steroid hormones. The fetal adrenal gland has a distinct pattern of steroid metabolism that is due to the relative lack of 3β‐hydroxysteroid dehydrogenase and the very active sulfotransferases and 16α‐hydroxylases. This distinctive pattern is probably confined to the fetal zane af the fetal adrenal cortex. This zone develops during gestatian, passibly under the influence of chorianic and fetal pituitary gonadatrapins, and involutes after birth. The fetal adrenal gland, though unable to form pragesterone, metabalizes it to a variety of hydraxylated steraids. Very early in development only 16α‐hydraxylase and 17‐hydroxylase can be demonstrated in the fetal adrenal gland in vitro. By 7 to 8 weeks 21‐hydroxylase and desmalase are active in vitro, and thereafter 11‐hydraxylase becomes detectable. The cancentrations af steroids in adrenal tissue and fetal blood and urine suggest that there is a preponderance of cartisone aver cortisol and that the corticasterone/cortisol ratio is higher in perinatal life than that found in the child or adult. The activity of the sulfotransferases of the fetus explains the preponderance of sulfurylated steraids in fetal and newborn fluids. Depending on the sex of the fetus, andragen synthesis may rise just before differentiation af the gonaducts and external genitalia. The fetal testis at this period has numerous large Leydig cells, which may also be under the influence of charianic ganadotropin. There is no evidence of impaired 3β‐hydroxysteroid dehydrogenase in the fetal testis, and testasterone is a major product of steroid metabolism in vitro.