Premium
Maternal drug exposure and fetal abnormalities; Material and methods
Author(s) -
Slone Dennis,
Hein Olli P.,
Monson Richard R.,
Shapiro Samuel,
Hartz Stuart C.,
Rosenberg Lynn
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973144part2648
Subject(s) - offspring , confounding , cohort , medicine , cohort study , drug , pregnancy , obstetrics , biology , psychiatry , genetics
Data derived from a cohort of 50,897 pregnancies that occurred between 1959 and 1965 are currently being evaluated to determine whether any associations between maternal drug exposure and abnormalities in the offspring exist. In this report, the cohort being studied is briefly described, and the methods used to identify associations, together with factors that confound them, are outlined. Also presented are the techniques used to control for these factors in evaluating the associations. Issues concerning causal interpretation of associations that remain after confounding factors have been controlled are discussed.