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Pharmacokinetics of intravenous theophylline
Author(s) -
Mitenko Paul A.,
Ogilvie Richard I.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973144part1509
Subject(s) - theophylline , aminophylline , pharmacokinetics , medicine , anesthesia , plasma concentration , metabolic clearance rate , plasma clearance , pharmacology , bronchodilator , elimination rate constant , intravenous infusions , disposition , asthma , volume of distribution , psychology , social psychology
Plasma theophylline concentrations were measured after single intravenous infusions of aminophylline to asthmatic patients and normal volunteers. Using two‐compartment kinetic analysis, no basic differences in drug disposition were found. For the 16 subiects studied the overall mean plasma clearance rate was 0.0719 I per kilogram per hour, and overall mean beta or slow disposition constant was 0.159 hr −1 , corresponding to a plasma half‐time of 4.36 hr. This information should be useful in determining precise dosage requirements for theophylline in clinical situations.