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Acute respiratory effects of ethanol in man
Author(s) -
Johnstone Robert E.,
Reier Charles E.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973144part1501
Subject(s) - kilogram , liter , anesthesia , dose , tidal volume , zoology , medicine , respiratory system , respiratory rate , apnea , ethanol , respiration , body weight , chemistry , heart rate , blood pressure , biology , biochemistry , anatomy
Six healthy subjects received ethanol 0.35, 0.70, and 1.05 ml per kilogram intravenously in 1 hour, causing average blood ethanol concentrations of 40, 99, and 121 mg per milliliter, respectively. Resting ventilatory minute volume (V E ) and end tidal carbon dioxide tension (P A CO 2 ) were inconsistently affected. The ventilatory response to CO 1 was depressed in a dose‐dependent manner. The P A CO 2 at a V E of 20 I per minute was 3.9 torr greater than control after the 1.05 ml per kilogram dosage. Respiratory exchange ratio decreased from 0.779 to 0.709 1 hour after the 1.05 ml per kilogram infusion. Vital capacity decreased from 5.42 to 5.09 1, and expiratory reserve volume decreased from 1.14 to 0.9311 hour following this dosage. Irregular ventilatory patterns with transient inspiratory and expiratory apnea were observed frequently following the 0.70 and 1.05 ml per kilogram dosages.