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Cireadian rhythm of therapeutie effectiveness of oxymetholone in paraplegie patients
Author(s) -
Ede Martin C. Moore,
Burr Robert G.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973143448
Subject(s) - circadian rhythm , excretion , hypercalciuria , endocrinology , rhythm , medicine , calcium , urinary calcium , urinary system , chemistry
Extensive hone demineralization and hypercalciuria occur in paraplegie patients during the first few months of immobilization. During this time, urinary calcium excretion has been shown to have a circadian rhythm with a maximal excretion at midday. Oxymetholone (Anapolon, Anadrol) timed to cover the period of maximum calcium loss resulted in a flattened urinary calcium rhythm and reduction in the 24 hour calcium excretion in 2 of 4 paraplegie subjects. The effectiveness of a single 10 mg dose given at various times of day was then compared in 29 acute paraplegie patients. Ten milligrams of oxymetholone given at 6 AM, before the peak in calcium excretion, produced a significant fall in the 24 hour calcium excretion, but similar doses at other times of day were ineffective. The findings are consistent with known circadian rhythms of bone metabolism and provide another example of a circadian rhythm in drug effectiveness.