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Positive inotropic effect of oral esproquin in normal subjects
Author(s) -
Kotelanski Bernardo,
Grozmann Roberto J.,
Cohn Jay N.
Publication year - 1973
Publication title -
clinical pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.941
H-Index - 188
eISSN - 1532-6535
pISSN - 0009-9236
DOI - 10.1002/cpt1973143427
Subject(s) - medicine , inotrope , heart rate , stroke volume , cardiac output , chronotropic , blood pressure , ejection fraction , vasodilation , hemodynamics , anesthesia , oral administration , cardiology , heart failure
The Hypertension and Glinical Hemodynamics Section, Veterans Administratian Hospital, and the Department of Medicine, Georgetown University School of Medicine An isoquinoline derivative, esproquin (NG 7197), was administered in single oral doses of 100, 200, or 300 mg to 15 normal volunteers. A dose‐related positive inotropic effect was characterized by an increase in cardiac output and stroke volume that persisted for about 4 hours without a significant change in heart rate associated with areduction in pre‐ejection period and an increase in mean systolic ejection rate. Arterial pressure rose with the lower doses, but diastolic press ure fell and forearm blood flow increased with the highest dose. These data indicate that oral administration of esproquin produces a sustained positive inotropic effect and that in Zarger doses peripheral vasodilatation results either from adrenergic blockade or a direct vascular effect. The drug deserves evaluation for the treatment of chronic heart failure.